Brain Monitoring as Easy as Cardiac Monitoring

Transform patient care in the ICU with rapid brain monitoring at the bedside that detects seizures, monitors for delirium, and minimizes the risk of misdiagnosis.

A Clinical Overlap

Hypoactive delirium and non-convulsive seizures can be clinically indistinguishable, though treatment approaches differ, making brain monitoring an important tool to help differentiate between them.

48% of ICU seizure patients experience delirium around the seizure episode; 42% of older adults with ICU delirium have seizure or epileptiform abnormalities — delirium and seizure are highly interrelated. In two separate single center studies.
Seizures
Delirium

Seizures

The Impact of Early Assessment with Ceribell

shorter median ICU length of stay with Ceribell vs. conventional EEG3
more patients from the Ceribell ICU cohort had better neurological outcomes*3
cases in which diagnostic suspicion changed4

Non-convulsive Status Epilepticus is a Neuro-Emergency in Acute Care

Up to 1/3 of neurological critical care patients are at risk for seizures, which may lead to permanent brain injury and increased risk of death. 5,6

— Indications for Emergent EEG —

Seizure Assessment7

  • Recent convulsive seizure without return to baseline
  • Episodic or repetitive movements concerning for seizure
  • Seizure activity requiring active medication titration

Post-Cardiac Arrest8,9

  • Post-ROSC without return to baseline/comatose
  • 2023 AHA Class 1 guideline
  • Sedated or TTM seizure monitoring

Altered Mental Status7

  • Altered mental status without explanation
  • Persistent altered state and acute brain injury
  • Unresponsive to treatment of primary condition, especially sepsis, hepatic failure

Time is Brain for Seizure Patients

Treatment Response Rates
Time in Seizure Associated with Increase in Mortality

Delirium

Recognizing and Monitoring Delirium Matters

Delirium is highly prevalent in ICU patients and leads to poor clinical and economic outcomes

Highly Prevalent

~31% of Intensive Care Unit patients12

Up to 80% of mechanically ventilated patients13

Poor Clinical Outcomes

60% more likely to develop dementia after surviving delirium in the ICU14

Each additional day of ICU delirium associated with a 10% increased risk of 6-month mortality13

High Economic Burden

2.2-days longer hospital LOS and $6,000 USD additional hospitalization costs (patients with acute respiratory failure)15

Each episode of delirium associated with up to $18,000 USD increased 30-day cumulative cost per visit16

Moving Beyond Traditional Delirium Assessments

Guideline Recommends Delirium Assessment in the ICU…

“Critically ill adults should be regularly assessed for delirium using a valid tool”17

“The Confusion Assessment Method for the ICU (CAM-ICU) and the Intensive Care Delirium Screening Checklist (ICDSC) are the most valid and reliable delirium monitoring tools in adult ICU patients”18

But These Assessments Fall Short

The “Snapshot” Problem: Twice a day static assessments may miss critical periods of brain dysfunction because delirium naturally waxes and wanes.

Patient Barriers: Assessments are often rendered unreliable by common ICU factors, such as deep sedation, acute neurological injuries, or language barriers between the patient and the nurse.19,20,21

Inconsistent Execution: Reliability of these tools is dependent on rigorous bedside training, regular documentation, and interprofessional rounding, processes that are frequently not completed.19,20,22,23

Missed Non-Convulsive Seizures: CAM-ICU and the ICDSC assessment cannot detect epileptiform abnormalities in the brain.

Ceribell: Clarity When It’s Critical

One Bedside Monitor. Two Vital Brain Insights.

Continuous Seizure Monitoring and Alerts

Delirium Screening and Monitoring

Remotely Review Patient Trends

Rapid Bedside Brain Monitoring

Setup in minutes with minimal training for routine bedside assessment of two common neurological threats in the ICU

Take Out the Guesswork

Access objective data needed to detect delirium and seizures and easy-to-interpret dual-indication insights to support clinical decision making

Capture the Fluctuation

Utilize artificial intelligence powered monitoring for real-time tracking of delirium and changes in subclinical seizure activity, including response to medications

New! CMS Grants NTAP for Ceribell Delirium Monitor

CMS (Centers for Medicare & Medicaid Services) granted a New Technology Add-on Payment (NTAP) for the Ceribell Delirium Monitor System.24 Eligible Medicare inpatient cases utilizing the system can receive up to $2,171 in incremental reimbursement.†

Learn how Clarity works →

Ceribell® Indications, Safety & Warnings

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Over 680 Hospitals** Use Ceribell And Counting

Adam Green, MD — Critical Care Intensivist, Cooper University Hospital
Mary Kay Bader, CCRN, CNRN, SCRN, CCNS — Neuroscience/Critical Care CNS, Mission Hospital

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Resources

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Sepsis Webinar: Point-Of-Care EEG for Severe Sepsis Patients and Why it Matters

Watch Our Webinar

Webinar

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Dr. Stephan Mayer Webinar: Post Cardiac Arrest Guidelines and Neuromonitoring In the ICU

Watch Our Webinar

Webinar

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Webinar: Evidence-based Insights for Non-convulsive Seizure Triage & Management in Critical and Emergency Care

Watch Our Webinar

Webinar

References and Citations

1. Frei A.I., et al. (2023) J Neurol. 271(1):231–240
2. Sambin S., et al. (2019) Front Neurol. 10:263
3. Desai, M., et al. (2025) Neurocrit Care. 42(1):108-117
4. Vespa, P.M., et al. (2020) Crit Care Med. 48(9):1249-1257
5. Laccheo, I., et al. (2015) Neurocrit Care. 22:202-211
6. De Marchis, G.M., et al. (2016) Neurology. 86(3):253-260
7. Herman, S.T., et al. (2015) J Clin Neurophysiol. 32(2):87-95
8. Panchal, A.R., et al. (2020) Circulation. 142(suppl 2):S366-S468
9. Perman, S.M., et al. (2024) Circulation. 149(5):e254-e273
10. Lowenstein, D.H., et al. (1993) Neurology. 43(3 Pt 1):483-488
11. Young, G.B., et al. (1996) Neurology. 47(1):83-89
12. Krewulak, K.D., et al. (2018) Crit Care Med. 46(12):2029-2035

13. Ely, E.W., et al. (2004). JAMA. 291(14):1753–62
14. Wang, S. et al. (2024) Alzheimers Dement, 20(1), 278-287
15. Taha A., et al. (2023) Medicine (Baltimore). 102(2):e32652
16. Kinchin, et al. (2021). Alzheimer’s & Dementia, 17(6)
17. Devlin, J.W., et al. (2018) Crit Care Med. 46(9):e825-873
18. Barr, J., et al. (2013) Crit Care Med. 41:263-306
19. Ragheb, J., et al. (2023) BMC Health Serv Res. 23,712
20. Meghani S., et al. (2024) Nurs Crit Care. 29(5):943-952
21. Fuentes AL., et al. (2026) Crit Care Med. 54(6):1464-1476
22. Devlin, J.W., et al. (2008) AJCC. 17(6): 555-566
23. Mailhot T., et al. (2025) Geriatr Nurs. 63:76-84
24. CMS FY 2027 IPPS Final Rule. CMS-1849-F, 91 Fed. Reg. 49742-49745, Aug. 4, 2026

*Using mRS greater than or equal to 4 at discharge as an indicator of functional disability. Results with Ceribell vs. matched conventional EEG.
**Based on Ceribell internal data; figure subject to change.
†Taking effect October 1, 2026.