Individuals without any prior EEG training can accurately determine whether the EEG represents seizures or nonseizure conditions

  • Individuals without EEG training can detect ongoing seizures or seizure-like rhythmic periodic patterns by listening to sonified EEG
  • Nonexperts listening to single-channel sonified EEGs detected seizures with remarkable sensitivity (students, 98%±5%; nurses, 95%±14%) compared to experts or nonexperts reviewing the same EEGs on visual display (neurologists,88%±11%; students, 76%±19%)
  • Nonexperts listening to sonified EEGs rated them as seizures with high specificity (students, 85%±9%; nurses, 82%±12%) compared to experts or nonexperts viewing the EEGs visually (neurologists, 90%±7%; students, 65%±20%)

The Ceribell circumferential montage EEG can be used in emergency situations to detect gross abnormalities

  • Full and reduced EEG demonstrated similar accuracy when read by neurologists (fm-EEG: 95%, rm-EEG: 95%, p = 0.29)
  • Resident physicians judged with similar accuracy (fm-EEG: 80%, rm-EEG: 80%, p = 0.05),
  • Medical student accuracy was comparable (fm-EEG: 60%, rm-EEG: 57%, p = 0.68)

Combining data from 16 studies, the prevalence of midline or parasagittal abnormalities was 0.71% (1,211 of 169,510)

  • The study clearly confirms that focal midline or parasagittal seizure are rare.
  • In a cohort of 300 patients, 17 were found to have seizure activity; of these, only two were documented to have focal midline or parasagittal seizures
  • Combining data from 16 studies, the prevalence of midline or parasagittal abnormalities was 0.71% (1,211 of 169,510) and both of these focal seizures were also visible in temporal EEG channels

The study makes a significant contribution to the ongoing efforts to improve access to real-time EEG acquisition and reduce time to diagnosis

  • The novel use of a simplified EEG montage paired with sonification system may be valuable in the acute assessment of patients with suspected NCSz, leading to more accurate diagnostic decision-making and increasing physicians’ confidence in their diagnostic and therapeutic plans.
  • A simplified system like “Rapid-EEG” appears to be a way to expand EEG monitoring to ICUs without expertise in EEG acquisition and interpretation

Ceribell electrode signal quality was equivalent to conventional EEG

  • The tested rapid response EEG system provides EEG data that is equivalent in quality to the recordings made using conventional EEG systems despite the fact that the rapid response system can be applied within a few minutes and with no reliance on specialized technologists
  • Simultaneous recordings taken with the rapid response EEG and two conventional EEG systems were found to match for the entire duration of the recording
  • Consecutive recordings performed in real life clinical ICU environment, Hjorth parameters, spike count, baseline wander, and kurtosis measures were statistically similar

Assessing the utility of continuous and spot EEG in a tertiary care center by quantifying access time and diagnostic yield

  • Even in a modern United States tertiary care setting with state-of-the-art EEG practice and 24 h on-call EEG technician services, there is a noticeable delay in access to EEG
  • EEG access time was 3.7 ± 4.1 h, ranging from half an hour to more than 24 h
  • Because non-convulsive seizures are associated with increased morbidity and mortality, more rapid acquisition of EEG in these cases might result in valuable changes in management
  • Technicians were asked to note specific reasons why an EEG might be delayed, which included technician or machine unavailability (33%)

This report confirms the ease of use and speed of acquisition and interpretation of Rapid EEG information

  • Conventional EEG was significantly delayed (11.2 ± 3.6 hours) compared with RR-EEG (5.0 ± 2.4 minutes; P < .005)
  • Use of RR-EEG helped clinicians rule out status epilepticus and prevent overtreatment in 4 of 10 cases [40%]
  • RR-EEG and conventional EEG systems yielded similar diagnostic information
  • This report confirms the ease of use and speed of acquisition and interpretation of EEG information at a community hospital setting using an RR-EEG device. This new technology has the potential to improve emergent clinical decision making and prevent overtreatment of patients in the intensive care unit setting while empowering nursing staff with useful diagnostic information in real time and at the bedside.

EEG recordings using a circumferential 10-electrode montage meet the gold standard for seizure detection

  • Removing confounding factors, the overall concordance between fm-EEG and rm-EEG increased from 79.7% to 99.0%, and the sensitivity and specificity of rm-EEG compared to fm-EEG in detecting seizure cases increased to 97.5% and 100.0%, respectively.
  • The concordance between fm-EEG and rm-EEG observed in Phase II… was 95%
  • These findings demonstrate that differences between fm-EEG and rm-EEG can largely be explained by variability in EEG pattern classification across readers and incorporation of asymmetric clinical information into EEG interpretation rather than by true detection failure of rm-EEG as a result of electrode reduction

Ceribell with Clarity provides 24/7 EEG monitoring with consistently high performance for seizure burden assessment and bedside alert

  • Of the 179 EEG recordings in which Claritγ detected no seizures, [Clarity had a] negative predictive value of 99%.
  • Individual expert raters displayed variability in both sensitivity (range 20–89%) and specificity (range 94–99%).
  • The sensitivity for identifying status epilepticus was 100%, [and] the specificity of the ≥ 90% seizure burden notification was 93.0%.