A Sampling of Clinical Data and Supporting Evidence

The Ceribell EEG system has been clinically validated across 80+ publications and abstracts, including reports on 2 multi-center trials

 

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Impact on Clinical Management

SAFER-EEG TRIAL: Shorter median ICU length of stays with Ceribell and more patients from the Ceribell cohort with better neurological outcomes compared to conventional EEG1

  • 4.1-day shorter median ICU length of stay with Ceribell vs. convEEG
  • 18% more patients from the Ceribell cohort had better neurological outcomes***
  • 19.4 hours faster door-to-EEG time
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2HELPS2B calibration graphic

SAFER-EEG TRIAL: Performance of the 2HELPS2B score with Ceribell is comparable to conventional EEG for forecasting seizure risk in acutely ill patients2

  • Comparable 72 hours in-hospital seizure risk forecasting with Ceribell vs. conventional EEG
  • If Ceribell 2HELPS2B=0, the risk of seizures in the next 24h is only ~2%

 

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Impact of Rapid-EEG Graphic

Ceribell use in the ED has the potential to positively impact the clinical management of suspected non-convulsive seizures3

This prospective study conducted at two ED sites evaluated rapid EEG impact on seizure management when used by emergency physicians. Ceribell changed clinical management for 53% of patients.

  • Ceribell expedited disposition of 21% of patients
  • ED physicians identified seizures with 100% sensitivity and 92% specificity when using Brain Stethoscope

 

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Improved clinical accuracy graphic

DECIDE TRIAL: Ceribell Point-of-Care EEG was demonstrated to significantly improve clinical accuracy and confidence4

The DECIDE trial was a prospective, multi-center observational study that evaluated the clinical impact of Point-of-Care EEG. The device was set up by neurology residents and fellows without prior experience with Ceribell EEG. The qualitative results came from evaluations in user surveys.

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Clarity Performance

Clarity ™ logo

Ceribell with Clarity offers 24/7 EEG monitoring with consistently high performance for detecting non-convulsive status epilepticus5,6

Retrospective assessment of clinical Ceribell EEGs across 11 centers evaluated the performance of Clarity to epileptologist consensus in generating bedside alerts for possible status epilepticus.

  • 95%  Sensitivity for alerting to suspected status epilepticus*
  • 97% Specificity for ruling out status epilepticus*
  • 99% NPV for ruling out seizure and status epilepticus**

*At ≥ 90% seizure burden

**At 0% seizure burden

Health Economics

Ceribell EEG is Associated with Improved Patient Care and Increased Reimbursement7

Retrospective 6-month review after POC EEG QI protocol implementation, compared to 6 months prior to POC EEG acquisition.

 

  • 3-day trend of shorter median LOS, resulting in ~$4,850 average cost savings per patient
  • 13% of Ceribell patients qualifying for seizure-associated CC or MCC reimbursement, leading to ~$7,300 average additional payment

Ceribell Point-of-Care EEG has the potential to alter the treatment course for patients with suspected seizures and may result in cost savings per patient8

This study built a two-armed cost–benefit model comparing decisions based on rapid EEG results with those based on clinical suspicion alone, using data from DECIDE, to examine the potential effect of Ceribell on hospital costs.

 

  • Rapid EEG savings were $5,633 per use case (95% PI: $4,649 to $6,617)
  • Cost savings were demonstrated in 75% of replications
  • 64% of variance in total costs was attributable to LOS for patients incorrectly diagnosed with seizures

Optimal Number of Electrodes

Ceribell montage EEG graphic

<1% of EEGs showed parasagittal seizures, all of which were visible in temporal channels and thus would be captured on Ceribell montage9

 

Ceribell montage EEG graphic

95% Concordance diagnosis or ruling out of seizure activity between conventional and reduced montage like Ceribell10

Signal Quality

Person wearing Ceribell electrodes being monitored

Ceribell EEG offers equivalent signal quality to conventional EEG11

Ceribell was compared to Natus and Nihon Kohden in three-way simultaneous recordings and demonstrated equivalence. Ceribell was also compared to conventional systems in consecutive recordings, demonstrating equivalence for all quality metrics apart from noise, where Ceribell had significantly lower 60 Hz noise.

 

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