Clinical Data and Supporting Evidence: Clarity Study

Fast. Accurate. Informed. Clear.

CERIBELL™ WITH CLARITY WAS DEMONSTRATED TO DIFFERENTIATE EEGS WITH AND WITHOUT STATUS EPILEPTICUS WITH HIGH SENSITIVITY AND SPECIFICITY.

Results from the Clarity study were recently published in Neurocritical Care journal.

Monitoring the Burden of Seizures and Highly Epileptiform Patterns in Critical Care with a Novel Machine Learning Method

Neurocritical Care. doi: 10.1007 s12028-020-01120-0, October 2020

Published by:
Baharan Kamousi, Suganya Karunakaran, Kapil Gururangan, Matthew Markert, Barbara Decker, Pouya Khankhanian, Laura Mainardi, James Quinn, Raymond Woo and Josef Parvizi

Retrospective assessment of 353 adult patients who underwent evaluation of possible seizures with Rapid Response EEG system

The study assessed the performance of Ceribell
with Clarity to triage seizure activity in critical care
and emergency department settings

Expert consensus

Majority agreement EEG reading from multiple EEG experts

Clarity

Ceribell with Clarity EEG interpretation

Current standard of care

Individual epileptologist’s EEG reading

Clarity for detection of status epilepticus

Clarity detected ≥ 90% seizure
burden, thereby triggering an alert for impending status epilepticus, in 9 out of 9 cases (100% sensitivity)

Clarity for ruling out seizure

Of the 179 EEG recordings in which
Clarity detected no seizures,
seizures were identified by the
expert reviewers in only 2 cases. In
both cases, the seizures were less
than 30 seconds in duration.

  • 10% of EEGs resulted in a bedside alert (had a
    seizure burden ≥ 90%)
  • 33% of EEGs had seizure or epileptiform
    abnormalities that did not result in a bedside
    alert (seizure burden between 1%-90%)
  • 57% of EEGs were identified as normal or slow
    (0% seizure burden)

All 4 neurologists have fellowship training in epilepsy

Variability in Status Epilepticus Detection